V Michael Holers Selected Research

Complement 3d Receptors (Complement Receptor 2)

5/2014	Deficiency of complement receptors CR2/CR1 in Cr2⁻/⁻ mice reduces the extent of secondary brain damage after closed head injury.
1/2013	Human complement receptor 2 (CR2/CD21) as a receptor for DNA: implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE).
6/2012	The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment.
1/2012	The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation.
11/2009	Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice.
3/2009	Increased B cell deletion and significantly reduced auto-antibody titre due to premature expression of human complement receptor 2 (CR2, CD21).
9/2005	Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection.
12/2004	Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor 2/complement receptor 1-deficient mice.

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V Michael Holers Research Topics

Disease

67	Rheumatoid Arthritis 01/2022 - 02/2002
47	Arthritis (Polyarthritis) 01/2022 - 02/2002
41	Inflammation (Inflammations) 01/2022 - 11/2003
14	Autoimmune Diseases (Autoimmune Disease) 12/2021 - 01/2003
11	Ischemia 01/2021 - 07/2001
10	Experimental Arthritis 01/2020 - 11/2002
9	Reperfusion Injury 01/2021 - 07/2001
7	Infections 11/2022 - 09/2005
6	Macular Degeneration (Age-Related Maculopathy) 01/2022 - 06/2009
6	Systemic Lupus Erythematosus (Libman-Sacks Disease) 04/2019 - 09/2004
6	Lupus Nephritis 05/2010 - 04/2002
5	Acute Kidney Injury (Acute Renal Failure) 01/2018 - 01/2001
4	Craniocerebral Trauma (Head Injury) 03/2016 - 06/2006
4	Proteinuria 09/2015 - 10/2003
4	Albuminuria 09/2015 - 04/2002
4	Choroidal Neovascularization 05/2013 - 03/2011
4	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 01/2013 - 06/2008
4	Respiratory Hypersensitivity 01/2012 - 12/2003
4	Renal Insufficiency (Renal Failure) 08/2007 - 01/2001
3	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 05/2021 - 01/2005
3	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2021 - 05/2009
3	Lung Diseases (Lung Disease) 01/2020 - 05/2009
3	Osteoarthritis 12/2019 - 11/2011
3	Arthralgia (Joint Pain) 11/2018 - 09/2015
3	Neoplasms (Cancer) 07/2017 - 07/2004
3	Cardiovascular Diseases (Cardiovascular Disease) 07/2017 - 11/2014
3	Pre-Eclampsia (Preeclampsia) 02/2016 - 04/2008
3	Joint Diseases (Joint Disease) 06/2015 - 12/2009
3	Thrombotic Microangiopathies 12/2014 - 12/2009
3	Neuroinflammatory Diseases 05/2014 - 06/2006
3	Traumatic Brain Injuries (Traumatic Brain Injury) 05/2014 - 06/2006
3	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 01/2005 - 01/2002
2	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2022 - 01/2020
2	Epidermolysis Bullosa Acquisita (Acquired Epidermolysis Bullosa) 01/2018 - 05/2007
2	Lung Injury 01/2018 - 03/2012
2	Synovitis 01/2017 - 03/2007
2	Closed Head Injuries 03/2016 - 05/2014
2	Gliosis 05/2014 - 04/2012
2	Hemolysis 06/2012 - 10/2011
2	Glomerulonephritis 06/2012 - 04/2004

Drug/Important Bio-Agent (IBA)

85	Complement System Proteins (Complement)IBA 01/2022 - 01/2001
42	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2002
40	AutoantibodiesIBA 01/2022 - 01/2004
25	AntibodiesIBA 01/2022 - 01/2001
22	Anti-Citrullinated Protein AntibodiesIBA 01/2022 - 01/2005
21	CollagenIBA 12/2021 - 08/2006
12	Rheumatoid FactorIBA 01/2022 - 01/2005
12	Immunoglobulin M (IgM)IBA 10/2021 - 01/2007
12	CytokinesIBA 01/2021 - 07/2006
11	Biomarkers (Surrogate Marker)IBA 10/2021 - 04/2008
10	EpitopesIBA 01/2022 - 02/2008
10	Complement Receptors (Complement Receptor)IBA 01/2020 - 10/2002
10	Complement Inactivating AgentsIBA 01/2020 - 01/2001
9	AntigensIBA 01/2022 - 03/2007
9	cyclic citrullinated peptideIBA 01/2021 - 01/2005
9	Immunoglobulin G (IgG)IBA 12/2019 - 11/2003
9	Complement Factor B (Factor B)IBA 07/2013 - 01/2005
8	Complement Factor H (Factor H)IBA 01/2018 - 11/2009
8	Complement 3d Receptors (Complement Receptor 2)IBA 05/2014 - 12/2004
7	Antigen-Antibody Complex (Immune Complex)IBA 06/2013 - 01/2003
6	Phospholipids (Phosphatides)FDA LinkGeneric 01/2020 - 12/2004
6	LectinsIBA 01/2020 - 08/2006
6	Complement C3 (C3 Complement)IBA 01/2018 - 03/2003
6	Monoclonal AntibodiesIBA 07/2013 - 03/2006
5	Biological ProductsIBA 05/2021 - 01/2007
5	Peptides (Polypeptides)IBA 01/2021 - 12/2003
5	acetyl 4-aminosalicylic acidIBA 01/2020 - 08/2013
5	Mannose-Binding Lectin (Mannan-Binding Lectin)IBA 09/2018 - 11/2010
4	Immunoglobulin A (IgA)IBA 01/2022 - 09/2013
4	AutoantigensIBA 01/2021 - 01/2003
4	EnzymesIBA 01/2021 - 01/2004
4	Immunoglobulins (Immunoglobulin)IBA 01/2020 - 02/2002
4	Mannose-Binding Protein-Associated Serine Proteases (Mannose-Binding Protein-Associated Serine Protease)IBA 01/2017 - 11/2010
4	Complement C3-C5 Convertases (C3 Convertase)IBA 05/2014 - 08/2003
3	Messenger RNA (mRNA)IBA 01/2022 - 08/2006
3	Complement Factor D (Factor D)IBA 01/2020 - 11/2016
3	AlbuminsIBA 01/2020 - 04/2002
3	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 12/2017 - 02/2016
3	Collagen Type II (Type II Collagen)IBA 02/2015 - 08/2006
3	ChemokinesIBA 11/2014 - 11/2010
3	DNA (Deoxyribonucleic Acid)IBA 01/2013 - 03/2005
3	AllergensIBA 01/2012 - 12/2003
3	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 11/2011 - 01/2001
2	complement C3d,gIBA 01/2021 - 09/2005
2	Blood Proteins (Serum Proteins)IBA 01/2020 - 04/2016
2	Aquaporin 4IBA 01/2019 - 11/2003
2	Serine (L-Serine)FDA Link 09/2018 - 01/2017
2	Bleomycin (Blenoxane)FDA LinkGeneric 01/2018 - 03/2012
2	CreatinineIBA 01/2018 - 04/2002
2	Collagen Type VIIIBA 01/2018 - 05/2007
2	LigandsIBA 01/2017 - 05/2013
2	Serine Proteases (Serine Protease)IBA 11/2016 - 11/2010
2	ferric oxide (iron oxide)IBA 11/2015 - 05/2010
2	ImmunosorbentsIBA 09/2013 - 01/2004
2	Retinaldehyde (Retinal)IBA 05/2013 - 03/2011
2	Fibrinogen (Factor I)FDA Link 02/2013 - 04/2006
2	Doxorubicin (Adriamycin)FDA LinkGeneric 02/2013 - 08/2007

Therapy/Procedure

9	Therapeutics 01/2021 - 12/2003
4	Lasers (Laser) 06/2013 - 03/2011
2	Transplantation 03/2015 - 06/2007